38 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Preparation of biotinylated allosamidins with strong chitinase inhibitory activities.
University of Tokyo
Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.
University of Tokyo
Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions.
University of Tokyo
Practical synthesis and evaluation of the biological activities of 1alpha,25-dihydroxyvitamin D3 antagonists, 1alpha,25-dihydroxyvitamin D3-26,23-lactams. Designed on the basis of the helix 12-folding inhibition hypothesis.
University of Tokyo
Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats.
University of Tokyo
Reduced folate derivatives are endogenous substrates for cMOAT in rats.
University of Tokyo
Primary active transport of peptidic endothelin antagonists by rat hepatic canalicular membrane.
University of Tokyo
SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail.
University of Tokyo
Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands.
University of Tokyo
Novel alpha-glucosidase inhibitors with a tetrachlorophthalimide skeleton.
University of Tokyo
Nonpeptide small-molecular inhibitors of dipeptidyl peptidase IV: N-phenylphthalimide analogs.
University of Tokyo
Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.
University of Tokyo
Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors.
University of Tokyo
Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors.
University of Tokyo
Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.
University of Tokyo
Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor alpha/delta dual agonists.
University of Tokyo
Synthesis of 1alpha,25-dihydroxyvitamin D3-26,23-lactams (DLAMs), a novel series of 1 alpha,25-dihydroxyvitamin D3 antagonist.
University of Tokyo
Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity.
University of Tokyo
Inhibition of dopamine receptors by endogenous amines: binding to striatal receptors and pharmacological effects on locomotor activity.
University of Tokyo
Role of the hydrophobic moiety of tumor promoters. Synthesis and activity of 2-alkylated benzolactams.
University of Tokyo
Protein kinase C modulators bearing dicarba-CLOSO-dodecaborane as a hydrophobic pharmacophore.
University of Tokyo
Potent estrogenic agonists bearing dicarba-closo-dodecaborane as a hydrophobic pharmacophore.
University of Tokyo
Synthesis, computer modeling and biological evaluation of novel protein kinase C agonists based on a 7-membered lactam moiety.
University of Tokyo
Clarification of the binding mode of teleocidin and benzolactams to the Cys2 domain of protein kinase Cdelta by synthesis of hydrophobically modified, teleocidin-mimicking benzolactams and computational docking simulation.
University of Tokyo
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
University of Tokyo
Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide.
University of Tokyo
Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in gene transfectant systems.
University of Tokyo
The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites.
University of Tokyo
Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus.
University of Tokyo
Physicochemical parameters responsible for the affinity of methotrexate analogs for rat canalicular multispecific organic anion transporter (cMOAT/MRP2).
University of Tokyo
Carrier-mediated hepatobiliary transport of a novel antifolate, N-[4-[(2,4-dianninopteridine-6-yl)methyl]-3,4-dihydro-2H-1,4-benzothiazin-7-yl]carbonyl-L-homoglutamic acid, in rats.
University of Tokyo
Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.
University of Tokyo
Characterization of uremic toxin transport by organic anion transporters in the kidney.
University of Tokyo
Novel potent nonpeptide aminopeptidase N inhibitors with a cyclic imide skeleton.
University of Tokyo
