PMID

Data

Article Title

Organization

Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.

Eli Lilly

Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds.

Pharma Research and Early

1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors: separation of desired cellular activity from undesired tissue accumulation through optimization of basic nitrogen pka.

Merck Research Laboratories

6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors.

Merck Research Laboratories

Nitrogen-containing bicyclic aromatic heterocyclic compound

Astellas Pharma

Discovery of orally bioavailable cathepsin S inhibitors for the reversal of neuropathic pain.

Novartis

Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.

Merck Frosst Centre For Therapeutic Research