PMID

Data

Article Title

Organization

Discovery of KDM5A inhibitors: Homology modeling, virtual screening and structure-activity relationship analysis.

Sichuan University

Recent Progress in Histone Demethylase Inhibitors.

University of Oxford

Inhibition of Histone Demethylases Offers a Novel and Promising Approach for the Treatment of Cancer and Other Diseases.

Therachem Research Medilab (India)

Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.

University of Oxford

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

The Institute of Cancer Research

Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors.

University of Oxford

Recent Advances with KDM4 Inhibitors and Potential Applications.

St. Jude Children'S Research Hospital

Discovery of Novel Pyrazole-Based KDM5B Inhibitor

Zhengzhou University

First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.

University of Oxford

Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B).

Zhengzhou University

Lysine demethylase 5B (KDM5B): A potential anti-cancer drug target.

Zhengzhou University

Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.

Genentech

Identification of potent, selective KDM5 inhibitors.

Constellation Pharmaceuticals

Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies.

Genentech

Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy.

Kyoto Prefectural University of Medicine

C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays.

Institute of Cancer Research

Structure-based design and discovery of potent and selective KDM5 inhibitors.

Celgene

Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.

Celgene Quanticel Research

From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors.

Genentech

Potent Inhibition of SARS-CoV-2 nsp14

University of Montpellier

The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family.

Cnrs

 

Calorimetric Studies on the Complexation of Several Ferrocene Derivatives by .alpha.- and .beta.-Cyclodextrin. Effects of Urea on the Thermodynamic Parameters

University of Miami

Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.

Johnson & Johnson Pharmaceutical

Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.

Universita Degli Studi Di Firenze

Role of hydrophilic interaction in binding of hydroxylated 3-deoxy C(19) steroids to the active site of aromatase.

Tohoku Pharmaceutical University