24 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities.
University of Dundee
Hot spot-based design of small-molecule inhibitors for protein-protein interactions.
University of Utah
Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses.
Janssen Research and Development
Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein-Protein Interactions?
University of Cambridge
Discovery of Pentacyclic Triterpenoid PROTACs as a Class of Effective Hemagglutinin Protein Degraders.
Peking University
Development of BromoTag: A "Bump-and-Hole"-PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins.
University of Dundee
Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity.
University of California Santa Cruz
Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL.
Janssen Research & Development
Understanding and Improving the Membrane Permeability of VH032-Based PROTACs.
University of California Santa Cruz
Small-Molecule Modulators of the Hypoxia-Inducible Factor Pathway: Development and Therapeutic Applications.
China Pharmaceutical University
Small molecule PROTACs in targeted therapy: An emerging strategy to induce protein degradation.
Shaoxing University
Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.
Arvinas