48 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Synthesis of fluorescent probes directed to the active site gorge of acetylcholinesterase.
The University of Montana
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.
University of Ljubljana
Ameliorative effects of amide derivatives of 1,3,4-thiadiazoles on scopolamine induced cognitive dysfunction.
University Institute of Pharmaceutical Sciences
Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes.
Ume£
Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents.
University of Ljubljana
Synthesis of aminoalkyl-substituted aurone derivatives as acetylcholinesterase inhibitors.
Kyung Hee University
Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.
University of Ljubljana
Synthesis of aminoalkyl-substituted coumarin derivatives as acetylcholinesterase inhibitors.
Kyung Hee University
Divergent structure-activity relationships of structurally similar acetylcholinesterase inhibitors.
Ume£
Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrum casuarinoides.
Fudan University
A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors.
University of Missouri St. Louis
Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer's disease.
Csir-Central Drug Research Institute
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Universit£
Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation.
Fudan University
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.
Eisai
Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.
University of South Carolina
Activation of the endocannabinoid system by organophosphorus nerve agents.
University of California
Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors.
Kyoto University
Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors.
Kyoto University
Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine hydrochloride (E2020) and related compounds
TBA
Novel inhibitors of AChE and A? aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease.
China Pharmaceutical University
From tryptophan-based amides to tertiary amines: Optimization of a butyrylcholinesterase inhibitor series.
University of Ljubljana
Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease.
University of Barcelona (Ub)
Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures.
Swedish Defence Research Agency
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.
East China University of Science and Technology
Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease.
China Pharmaceutical University
Design, synthesis, and evaluation of isoflavone analogs as multifunctional agents for the treatment of Alzheimer's disease.
Chinese Academy of Medical Sciences and Peking Union Medical College
Coumarin derivatives as potential inhibitors of acetylcholinesterase: Synthesis, molecular docking and biological studies.
Panjab University
A new lateral root growth inhibitor from the sponge-derived fungus Aspergillus sp. LS45.
Ningbo University
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Csir-Central Drug Research Institute
Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model.
Julius Maximilian University W£Rzburg
Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms.
China Pharmaceutical University
In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor.
Universidade De £Vora
Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.
Warner-Lambert
Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives.
Universidade Federal Do Rio Grande Do Sul
Druggability Assessment of Targets Used in Kinetic Target-Guided Synthesis.
University of Groningen
Design, synthesis and pharmacological evaluation of some novel indanone derivatives as acetylcholinesterase inhibitors for the management of cognitive dysfunction.
Panjab University
The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.
University of Ljubljana
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives.
Eisai
A FLT3-inhibitory constituent from the rhizomes of Anemarrhena asphodeloides.
Gyeongsang National University