Compile Data Set for Download or QSAR
Report error Found 170 Enz. Inhib. hit(s) with all data for entry = 50007595
Target5-hydroxytryptamine receptor 1A(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataEC50:  0.120nMAssay Description:Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] A(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of recombinant human MAOA expressed in baculovirus infected BTI insect cells using p-tyramine as substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8964(CHEMBL75274 | N-[8-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 0.660nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM10469(CHEMBL424707 | Bis-THA inhibitor 8 | N-[9-(1,2,3,4...)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM10592(7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11...)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of human Acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM10592(7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11...)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of human Acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510840(CHEMBL4456928)
Affinity DataIC50: 0.860nMAssay Description:Inhibition of human serum butyrylcholinesterase using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510844(CHEMBL4451532)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition by E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510843(CHEMBL4466652)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition by E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510840(CHEMBL4456928)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human Acetylcholinesterase using acetylthiocholine as substrate preincubated for 20 mins followed by substrate addition by Ellman's met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50433323(CHEMBL2376472)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate pretreated 5 mins followed by substrate addition and measured after 2 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Bovine)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM10592(7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of bovine erythrocyte acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Bovine)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM10592(7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11...)
Affinity DataIC50: 4.23nMAssay Description:Inhibition of bovine erythrocyte acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM132072(US8841453, 2)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human plasma butyrylcholinesterase using butyrylthiocholine as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50006627(CHEMBL3235503)
Affinity DataIC50: 5nMAssay Description:Inhibition of human acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510834(CHEMBL4569511)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition by E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50006627(CHEMBL3235503)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human serum butyrylcholinesterase using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human acetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8979(CHEMBL486901 | N-[2-(1-benzylpiperidin-4-yl)ethyl]...)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat cortex homogenate acetylcholinesterase by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510853(CHEMBL4563881)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat synaptosome SERT assessed as reduction in [3H]5-HT uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50175503(Dimethyl-carbamic acid (R)-2-methyl-1-[2-(4-nitro-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat synaptosome SERT assessed as reduction in [3H]5-HT uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50080157((RS)-tacrine(10)-hupyridone | 5-[10-(1,2,3,4-Tetra...)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of rat cortex homogenate acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50281388(CHEMBL4173258)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3R expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 11nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate pretreated followed by substrate addition and measured after 2 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human CholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Mouse)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50175503(Dimethyl-carbamic acid (R)-2-methyl-1-[2-(4-nitro-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of mouse brain acetylcholinesterase by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Mouse)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510853(CHEMBL4563881)
Affinity DataIC50: 14nMAssay Description:Inhibition of mouse brain acetylcholinesterase by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50433930(CHEMBL2380613)
Affinity DataIC50: 14nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate pretreated 5 mins followed by substrate addition and measured after 2 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510836(CHEMBL4534662)
Affinity DataIC50: 16nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pretreated followed by substrate addition and measured after 2 mins by El...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510861(CHEMBL4541077)
Affinity DataIC50: 18nMAssay Description:Inhibition of human butyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50433323(CHEMBL2376472)
Affinity DataIC50: 19nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition and measured after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8987(6-chlorotacrine.HCl | CHEMBL486698 | 6-chloro-1,2,...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition by E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510839(CHEMBL4536838)
Affinity DataIC50: 22nMAssay Description:Inhibition of human butyrylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 23nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510861(CHEMBL4541077)
Affinity DataIC50: 26nMAssay Description:Inhibition of human acetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510851(CHEMBL4592066)
Affinity DataIC50: 27nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins followed by substrate addition and measured up to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human acetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Electric eel)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510841(CHEMBL4522757)
Affinity DataIC50: 30nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pretreated followed by substrate addition and measured after 2 mins by El...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510839(CHEMBL4536838)
Affinity DataIC50: 31nMAssay Description:Inhibition of human acetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant human MAOA expressed in baculovirus infected BTI insect cells using p-tyramine as substrate by Amplex red reagent/horseradi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Bovine)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM10592(7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11...)
Affinity DataIC50: 36.1nMAssay Description:Inhibition of bovine erythrocyte acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Bovine)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50079863((rac)15-ethyl-10-azatetracyclo[11.3.1.02,11.04,9]h...)
Affinity DataIC50: 39nMAssay Description:Inhibition of bovine erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50175500((S)-4-(1-(methylamino)-3-(4-nitrophenoxy)propyl)ph...)
Affinity DataIC50: 42nMAssay Description:Inhibition of rat synaptosome SERT assessed as reduction in [3H]5-HT uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510852(CHEMBL4554595)
Affinity DataIC50: 42nMAssay Description:Inhibition of rat synaptosome SERT assessed as reduction in [3H]5-HT uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510841(CHEMBL4522757)
Affinity DataIC50: 43nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate pretreated followed by substrate addition and measured after 2 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 44nMAssay Description:Inhibition of rat serum butyrylcholinesterase using butyrylthiocholine as substrate in presence of AChE inhibitor BW284C51 by spectrophotometric meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510862(CHEMBL4468902)
Affinity DataIC50: 44nMAssay Description:Inhibition of rat synaptosome SERT assessed as reduction in [3H]5-HT uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50458225(Ciproxifan)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3R expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510836(CHEMBL4534662)
Affinity DataIC50: 53nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate pretreated followed by substrate addition and measured after 2 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
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