PMID

Data

Article Title

Organization

Systematic Study of Effects of Structural Modifications on the Aqueous Solubility of Drug-like Molecules.

Yale University

Irregularities in enzyme assays: The case of macrophage migration inhibitory factor.

Yale University

Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor.

University of Otago

Discovery of novel inhibitors targeting the macrophage migration inhibitory factor via structure-based virtual screening and bioassays.

Zhejiang University

Virtual screening and optimization yield low-nanomolar inhibitors of the tautomerase activity of Plasmodium falciparum macrophage migration inhibitory factor.

Yale University

An integrative in silico methodology for the identification of modulators of macrophage migration inhibitory factor (MIF) tautomerase activity.

Brain Mind Institute

Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.

Yale University

Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography.

Yamanouchi Pharmaceutical

Synthesis and bio-evaluation of human macrophage migration inhibitory factor inhibitor to develop anti-inflammatory agent.

Institute of Chemical Biology

Benzisothiazolones as modulators of macrophage migration inhibitory factor.

Yale University

Receptor agonists of macrophage migration inhibitory factor.

Yale University

Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF).

Yale University

Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site.

Sanofi-Aventis

Novel derivatives of ISO-1 as potent inhibitors of MIF biological function.

Piramal Life Sciences

Discovery of human macrophage migration inhibitory factor (MIF)-CD74 antagonists via virtual screening.

Yale University

Phenolic hydrazones are potent inhibitors of macrophage migration inhibitory factor proinflammatory activity and survival improving agents in sepsis.

The New York School of Medicine

Critical modifications of the ISO-1 scaffold improve its potent inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity.

Institute For Medical Research

Classification of chemical compounds by protein-compound docking for use in designing a focused library.

National Institute of Advanced Industrial Science and Technology (Aist)

Repurposing old drugs as novel inhibitors of human MIF from structural and functional analysis.

Wuhan University

Structural modification aimed for improving solubility of lead compounds in early phase drug discovery.

Indian Institute of Technology (B.H.U.)

Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF).

University of Groningen

7-Hydroxycoumarins Are Affinity-Based Fluorescent Probes for Competitive Binding Studies of Macrophage Migration Inhibitory Factor.

University of Groningen

Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity.

Institute For Medical Research

Inhibition of Macrophage Migration Inhibitory Factor by a Chimera of Two Allosteric Binders.

L2 Diagnostics

Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF).

University of California-San Diego

Advances and Insights for Small Molecule Inhibition of Macrophage Migration Inhibitory Factor.

Yale University

Discovery of chromenes as inhibitors of macrophage migration inhibitory factor.

University of Groningen

Adding a Hydrogen Bond May Not Help: Naphthyridinone vs Quinoline Inhibitors of Macrophage Migration Inhibitory Factor.

Yale University

Design, Synthesis, and Biological Activity of New N-(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension.

Hospital Marie Lannelongue

PXD101 analogs with L-phenylglycine-containing branched cap as histone deacetylase inhibitors.

Shandong University

 

Novel 2(3H)-benzothiazolones as highly potent and selective sigma-1 receptor ligands

Universite De Lille