86 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
Northwestern University
2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity.
Northwestern University
Cell-permeable inhibitors of neuronal nitric oxide synthase open new prospects for the treatment of neurological disorders.
Vibrant Pharma
Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.
Northwestern University
Structure-based design of bacterial nitric oxide synthase inhibitors.
University of California
Combination of chiral linkers with thiophenecarboximidamide heads to improve the selectivity of inhibitors of neuronal nitric oxide synthase.
Northwestern University
Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.
Northwestern University
Simplified 2-aminoquinoline-based scaffold for potent and selective neuronal nitric oxide synthase inhibition.
Northwestern University
Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma.
Northwestern University
An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors.
Northwestern University
Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
Northwestern University
In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Northwestern University
Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.
Northwestern University
Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.
University of California
Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.
Northwestern University
New hypotheses for the binding mode of 4- and 7-substituted indazoles in the active site of neuronal nitric oxide synthase.
Universit£
Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).
Neuraxon
Synthesis and evaluation of pyrido[1,2-a]pyrimidines as inhibitors of nitric oxide synthases.
Christian-Albrechts-University of Kiel
Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.
Neuraxon
Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.
Queen'S University
Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.
Northwestern University
Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.
Northwestern University
Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.
Northwestern University
Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.
Northwestern University
Novel inhibitors of neuronal nitric oxide synthase with potent antioxidant properties.
Institut Henri Beaufour
1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase.
Northwestern University
Intramolecular hydrogen bonding: a potential strategy for more bioavailable inhibitors of neuronal nitric oxide synthase.
Northwestern University
3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors.
Neuraxon
Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.
Neuraxon
Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.
Neuraxon
Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase.
Northwestern University
Synthesis and evaluation of fluorescent heterocyclic aminoadamantanes as multifunctional neuroprotective agents.
North-West University
Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.
Northwestern University
Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.
Northwestern University
N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase.
Università
Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.
Northwestern University
Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.
Northwestern University
2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I.
University of Pennsylvania
Potent and selective neuronal nitric oxide synthase inhibitors with improved cellular permeability.
Northwestern University
Eusynstyelamides A, B, and C, nNOS inhibitors, from the ascidian Eusynstyela latericius.
Institute of Marine Science
1,2-diaminobenzimidazoles : Selective inhibitors of nitric oxide synthase derived from aminoguanidine
TBA
L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.
Northwestern University
Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.
Northwestern University
Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.
Northwestern University
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile.
Université
4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase.
Upres-Ea 3915
Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.
Northwestern University
Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.
Northwestern University
2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.
Northwestern University
Structure-activity relationships of potent, selective inhibitors of neuronal nitric oxide synthase based on the 6-phenyl-2-aminopyridine structure.
Pfizer
Inhibition of nNOS activity in rat brain by synthetic kynurenines: structure-activity dependence.
Universidad De Granada
Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.
Université
Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.
Astrazeneca R&D Charnwood
3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.
Astrazeneca R&D Charnwood
Evaluation of new L-thiocitrulline derivatives as inhibitors of nitric oxide synthase.
Wake Forest University
Guanidine-substituted imidazoles as inhibitors of nitric oxide synthase.
Wake Forest University Winston-Salem
Optimization of Blood-Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold.
Northwestern University
A new class of selective and potent inhibitors of neuronal nitric oxide synthase.
Pfizer
First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
Northwestern University
Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.
Abbott Laboratories
Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.
Northwestern University
Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma.
University of Chieti "G. D'Annunzio
Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.
Northwestern University
Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.
Northwestern University
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
Northwestern University
2-(2-indolyl-)-4(3H)-quinazolines derivates as new inhibitors of AChE: design, synthesis, biological evaluation and molecular modelling.
Sun Yat-Sen University
Identification and characterization of novel somatostatin antagonists.
Cyenamid Agricultural Research Center
Pharmacologic characterization of CI-996, a new angiotensin receptor antagonist.
Parke-Davis Pharmaceutical Research
Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes.
Portland State University
Covalent reactions of wortmannin under physiological conditions.
Massachusetts General Hospital