PMID

Data

Article Title

Organization

Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties.

University of Antwerp

Synthesis and biological activity of ketomethylene pseudopeptide analogues as thrombin inhibitors.

Thrombosis Research Institute

Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.

The Bristol-Myers Squibb Pharmaceutical Research Institute

Synthesis of potent and selective inhibitors of human plasma kallikrein.

The Procter & Gamble

 

L-373,890, An achiral, noncovalent, subnanomolar thrombin inhibitor

TBA

 

RATIONAL DESIGN, SYNTHESIS, AND SERINE PROTEASE INHIBITORY ACTIVITY OF NOVEL P₁-ARGININOYL HETEROCYCLES

TBA

A novel series of potent and selective small molecule inhibitors of the complement component C1s.

3-Dimensional Pharmaceuticals

Synthesis of potent and highly selective nonguanidine azetidinone inhibitors of human tryptase.

The Bristol-Myers Squibb Pharmaceutical Research Institute

N,N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors.

Millennium Pharmaceuticals

Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs.

Millennium Pharmaceuticals

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors.

Millennium Pharmaceuticals

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs.

Millennium Pharmaceuticals

1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma.

Shionogi

Synthesis, SAR and in vivo activity of novel thienopyridine sulfonamide pyrrolidinones as factor Xa inhibitors.

RhôNe-Poulenc Rorer

Secondary structure peptide mimetics: design, synthesis, and evaluation of beta-strand mimetic thrombin inhibitors.

Molecumetics

Alkoxide-catalyzed ring-opening of a novel homosaccharin derivative: synthesis of potent, selective P3-lactam thrombin inhibitors containing P4-o-alkoxycarbonylbenzylsulfonamide residues.

Corvas International

New orally active serine protease inhibitors.

Minase Research Institute

New leupeptin analogues: synthesis and inhibition data.

University of Arkansas