PMID

Data

Article Title

Organization

Synthesis and optimization of novela-phenylglycinamides as selective TRPM8 antagonists.

Kissei Pharmaceutical

Tryptamine-Based Derivatives as Transient Receptor Potential Melastatin Type 8 (TRPM8) Channel Modulators.

University of Salerno

Structure-activity relationships of the prototypical TRPM8 agonist icilin.

National Research Council

Effect of acyclic monoterpene alcohols and their derivatives on TRP channels.

Sapienza University of Rome

Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist.

Raqualia Pharma

Optimization of potency and pharmacokinetic properties of tetrahydroisoquinoline transient receptor potential melastatin 8 (TRPM8) antagonists.

Amgen

Synthesis and pharmacological evaluation of novel N-aryl-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamides as TRPM8 antagonists.

Glenmark Pharmaceuticals

3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.

Sapienza University of Rome

Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds.

Sapienza University of Rome

Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists.

Amgen

Design and optimization of benzimidazole-containing transient receptor potential melastatin 8 (TRPM8) antagonists.

Janssen Pharmaceutica

Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia.

Janssen Pharmaceutica

Bioactive prenylogous cannabinoid from fiber hemp (Cannabis sativa).

Universita` Del Piemonte Orientale

(-)-Menthylamine derivatives as potent and selective antagonists of transient receptor potential melastatin type-8 (TRPM8) channels.

Sapienza University of Rome

Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens.

Università

New TRPM8 blockers exert anticancer activity over castration-resistant prostate cancer models.

University of Salerno

Structural and in Vitro Functional Characterization of a Menthyl TRPM8 Antagonist Indicates Species-Dependent Regulation.

Marshall University

Identification of N-acyl-N-indanyl-?-phenylglycinamides as selective TRPM8 antagonists designed to mitigate the risk of adverse effects.

Kissei Pharmaceutical

Cannabitwinol, a Dimeric Phytocannabinoid from Hemp,

University of Naples Federico Ii

Exploration of TRPM8 Binding Sites by ?-Carboline-Based Antagonists and Their In Vitro Characterization and In Vivo Analgesic Activities.

University of Salerno

Tetrahydroisoquinoline-Derived Urea and 2,5-Diketopiperazine Derivatives as Selective Antagonists of the Transient Receptor Potential Melastatin 8 (TRPM8) Channel Receptor and Antiprostate Cancer Agents.

National Research Council

Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity.

University of Salerno

Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine.

TBA

Iodine-mediated cyclization of cannabigerol (CBG) expands the cannabinoid biological and chemical space.

Universit£

Iodine-Promoted Aromatization of p-Menthane-Type Phytocannabinoids.

University of Eastern Piedmont