PMID

Data

Article Title

Organization

Synthesis and antibacterial activity of new tetracyclic quinolone antibacterials.

Kanebo

Synthesis and bacterial DNA gyrase inhibitory properties of a spirocyclopropylquinolone derivative.

Sterling-Winthrop Research Institute

Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H- pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin).

Kansas University

 

The antitumor activity of novel pyrazoloquinoline derivatives

TBA

Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase II? Interactions.

Charles University

Novel oxazolidinone-quinolone hybrid antimicrobials.

Vicuron Pharmaceuticals

Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II ? over ?.

Istituto Italiano Di Tecnologia

New series of isoxazole derivatives targeting EGFR-TK: Synthesis, molecular modeling and antitumor evaluation.

Mansoura University

Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches.

Shandong University

Garcinol and Related Polyisoprenylated Benzophenones as Topoisomerase II Inhibitors: Biochemical and Molecular Modeling Studies.

European Biomedical Research Institute of Salerno (Ebris)

Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens.

Procter & Gamble Pharmaceuticals

seco-Cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties.

Bayer

DNA gyrase inhibitory and antimicrobial activities of some diphenic acid monohydroxamides.

R.W. Johnson Pharmaceutical Research Institute

Design and synthesis of thienopyrimidine urea derivatives with potential cytotoxic and pro-apoptotic activity against breast cancer cell line MCF-7.

Cairo University

Novel ciprofloxacin hybrids using biology oriented drug synthesis (BIODS) approach: Anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis, topoisomerase II inhibition, and antibacterial activity.

Cairo University

Design, synthesis and screening of 1, 2, 4-triazinone derivatives as potential antitumor agents with apoptosis inducing activity on MCF-7 breast cancer cell line.

Port Said University