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Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8- difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarb oxylic acid and related derivatives.

Sterling Winthrop Pharmaceuticals Research Division

Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities.

Toho University

Design, synthesis and structure-activity relationship studies of novel indazole analogues as DNA gyrase inhibitors with Gram-positive antibacterial activity.

Dainippon Pharmaceutical

Synthesis and biological testing of non-fluorinated analogues of levofloxacin.

Procter & Gamble Pharmaceuticals

Preparation of 5-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyloxy)-6-hydroxynap htho[2,3- f]quinoline-7,12-dione (FT-Alz), a new-type, potentially antitumor substance with various biological activities.

Institute of Bioorganic Chemistry

 

The antitumor activity of novel pyrazoloquinoline derivatives

TBA

Inhibitory activities against topoisomerase I and II by polyhydroxybenzoyl amide derivatives and their structure-activity relationship.

Kumamoto University

Synthesis and biological activities of NB-506 analogues modified at the glucose group.

Banyu Tsukuba Research Institute

Design, Synthesis and Anticancer Evaluation of New Substituted Thiophene-Quinoline Derivatives.

Kyushu Institute of Technology1-1 Sensuicho

Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506.

Banyu Tsukuba Research Institute

Discovery of 4,6-

Hubei University of Technology

Design, synthesis and biological evaluation of 1,4-dihydroxyanthraquinone derivatives as anticancer agents.

Guangxi University

Synthetic lanostane-type triterpenoids as inhibitors of DNA topoisomerase II.

Osaka University of Pharmaceutical Sciences

Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position.

Daiichi Pharmaceutical

Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 1.

Dainippon Pharmaceutical

seco-Cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties.

Bayer

Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611.

Umr 176 Cnrs/Institut Curie

Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model.

The University of Texas At Austin

Synthesis and antitumor activity of 4-aminomethylthioxanthenone and 5-aminomethylbenzothiopyranoindazole derivatives.

Sanofi Winthrop

Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors.

University of North Carolina At Chapel Hill

Dicationic diarylfurans as anti-Pneumocystis carinii agents.

Georgia State University

9-substituted acridine derivatives with long half-life and potent antitumor activity: synthesis and structure-activity relationships.

Sloan-Kettering Institute For Cancer Research

6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents.

Ewha Womans University