30 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
Organization
Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS).
Monash University (Parkville Campus)
Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3.
Amgen
Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate.
Monash University (Parkville Campus)
Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3.
The Walter and Eliza Hall Institute of Medical Research
Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.
Abbott Laboratories
Substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 ion channel blockers. Part 2.
Glaxosmithkline
N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 inhibitors. Part 1.
Glaxosmithkline
Selective Kv1.5 blockers: development of (R)-1-(methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia.
Wyeth Research
4-Phenoxybutoxy-substituted heterocycles--a structure-activity relationship study of blockers of the lymphocyte potassium channel Kv1.3.
University of California
Gamma-pyrone natural products--a privileged compound class provided by nature.
Institute of Molecular Physiology
Immunosuppressive effects of new thiophene-based KV1.3 inhibitors.
University of Ljubljana
A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone.
Institute of Medical Research Biotechnology Centre
A three-residue, continuous binding epitope peptidomimetic of ShK toxin as a Kv1.3 inhibitor.
Institute of Medical Research
Jatrophane Diterpenoids with Kv1.3 Ion Channel Inhibitory Effects from
Huazhong University of Science and Technology
Potent Kv1.3 inhibitors from correolide-modification of the C18 position.
Merck Research Laboratories
Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: synthesis and immunosuppressive activity.
Institute of Medical Research Biotechnology Centre
Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1.5.
Aventis Pharma Deutschland
Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3.
University of Kiel
Blockers of human T cell Kv1.3 potassium channels using de novo ligand design and solid-phase parallel combinatorial chemistry.
University of California
Alkoxypsoralens, novel nonpeptide blockers of Shaker-type K+ channels: synthesis and photoreactivity.
University of Kiel
Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels.
University of Ljubljana
Diaryl macrocyclic compound and pharmaceutical composition, and use thereof
Primegene (Beijing)
PYRIDINE DERIVATIVES WITH N-LINKED CYCLIC SUBSTITUENTS AS cGAS INHIBITORS
Boehringer Ingelheim International