The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.6M data for 1.1M Compounds and 8.9K Targets. Of those, 1,154K data for 533K Compounds and 4.4K Targets were curated by BindingDB curators.

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68 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

Article Title
An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold.EBI
University of KwaZulu-Natal
Synthesis of fluorine substituted pyrazolopyrimidines as potential leads for the development of PET-imaging agents for the GABAA receptors.EBI
ABX advanced biochemical compounds GmbH
Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides.EBI
Universit£ di Pisa
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.EBI
Universit£ degli Studi di Urbino Carlo Bo
Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor.EBI
Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors.EBI
Lund University
Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor.EBI
Universita di Pisa
Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site.EBI
Johannes Gutenberg University
Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.EBI
Università di Pisa
Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage.EBI
Università degli Studi di Firenze
High affinity central benzodiazepine receptor ligands: synthesis and biological evaluation of a series of phenyltriazolobenzotriazindione derivatives.EBI
Università di Pisa
Synthesis and benzodiazepine receptor affinity of pyrazolo[1,5-a]pyrimidine derivatives. 3. New 6-(3-thienyl) series as alpha 1 selective ligands.EBI
University of Firenze
Benzodiazepine receptor ligands. 7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) derivative: an anxioselective agent in rodents.EBI
Università degli Studi di Firenze
Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.EBI
Università di Pisa
Homology modeling and atomic level binding study of GABA(A) receptor with novel enaminone amides.EBI
Wuhan Institute of Technology
Agonists of the ?-aminobutyric acid type B (GABAEBI
University of Mississippi
A new class of pyrazolo[5,1-c][1,2,4]triazines as ?-aminobutyric type A (GABAEBI
Universit£ degli Studi di Firenze
Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors.EBI
Amgen Inc.
Structure-Function Evaluation of Imidazopyridine Derivatives Selective for ?-Subunit-Containing ?-Aminobutyric Acid Type A (GABAEBI
Johannes Gutenberg University Mainz
Discovery of the first low-shift positive allosteric modulators for the muscarinic M1 receptor.EBI
Roche Pharma Research and Early Development
Design, synthesis and biological evaluation of 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine derivatives as c-Met inhibitors.BDB
Tianjin University of Science and Technology
Evaluation of 2-indolcarbohydrazones as potent a-glucosidase inhibitors, in silico studies and DFT based stereochemical predictions.BDB
Universiti Teknologi MARA (UiTM)
Design, Synthesis, and Biological Evaluation of Novel Benzoyl Diarylamine/ether Derivatives as Potential Anti-HIV-1 Agents.BDB
Shandong University
Structure and Inhibition of Microbiome -Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.BDB
University of North Carolina at Chapel Hill
Type II Inhibitors Targeting CDK2.BDB
University of Oxford