Found 71 Enz. Inhib. hit(s) with all data for entry = 50002028 TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 251nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 521nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 275nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from human GABA-A receptor alpha2beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 962nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 870nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 4.48E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 238nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 311nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 70nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 80nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 1.85E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 649nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 349nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 289nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 414nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 62nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 232nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 552nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 1.47E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(RAT)
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 218nMAssay Description:Positive allosteric modulation of rat M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from human GABA-A receptor alpha1beta2gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-3/gamma-2(Rattus norvegicus (Rat))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha2beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Rattus norvegicus (Rat))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha3beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2(Rattus norvegicus (Rat))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from rat GABA-A receptor alpha5beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 1.47E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 399nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 2.15E+3nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 420nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 104nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >2.40E+4nMAssay Description:Displacement of [3H]-flumazenil from human GABA-A receptor alpha5beta3gamma2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 50nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: 172nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Roche Pharma Research And Early Development
Curated by ChEMBL
Roche Pharma Research And Early Development
Curated by ChEMBL
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human wild type M1 receptor assessed as increase in acetylcholine-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
