BDBM50240772 (1R,2S)-(-)-2-phenylcyclopropylamine::(1R,2S)-2-phenylcyclopropanamine::(tranylcypromine)2-Phenyl-cyclopropylamine::2-Phenyl-cyclopropylamine::CHEMBL1179::Parnate::TRANYLCYPROMINE::TRANYLCYPROMINE HYDROCHLORIDE::US10836743, Compound TCP::US8993808, Tranylcypromine::US9180183, Tranylcypromine::cid_2723716::rel-Tranylcypromine
SMILES N[C@@H]1C[C@H]1c1ccccc1
InChI Key InChIKey=AELCINSCMGFISI-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 123 hits for monomerid = 50240772
Affinity DataIC50: 4.5nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inhibition of recombinant human MAOB expressed in baculovirus infected BTI insect cells using beetle luciferin as substrate after 1 hr by MAO-Glo ass...More data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Inhibition of human recombinant soluble MAO-B expressed in Pichia pastoris incubated for 30 mins prior to substrate addition measured after 60 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMAssay Description:Compound was evaluated for inhibition of Microbial tyramine oxidase; competitiveMore data for this Ligand-Target Pair
Affinity DataIC50: 85nMAssay Description:Inhibition of recombinant human MAOA expressed in baculovirus infected BTI insect cells using beetle luciferin as substrate after 1 hr by MAO-Glo ass...More data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Mixed inhibition of CYP2A6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Inhibition of MAOB (unknown origin) by Promega MAO-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMpH: 7.5Assay Description:Human recombinant monoamine oxidase proteins MAO-A and MAO-B were purchased from Sigma Aldrich. MAOs catalyze the oxidative deamination of 1, 2 and 3...More data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 800nMAssay Description:Inhibition of recombinant human MAOB incubated for 15 mins measured after 30 mins by luminescence-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 890nMAssay Description:Inhibition of human recombinant MAOB expressed in Pichia pastoris incubated for 15 mins prior to substrate addition measured after 30 mins by lumines...More data for this Ligand-Target Pair
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of MAOA (unknown origin) by Promega MAO-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of recombinant human MAOA incubated for 15 mins measured after 30 mins by luminescence-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of human recombinant MAOA expressed in Pichia pastoris incubated for 15 mins prior to substrate addition measured after 30 mins by lumines...More data for this Ligand-Target Pair
Affinity DataKi: 1.80E+3nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane incubated for 120 mins by solid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomeMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMpH: 7.5Assay Description:Human recombinant monoamine oxidase proteins MAO-A and MAO-B were purchased from Sigma Aldrich. MAOs catalyze the oxidative deamination of 1, 2 and 3...More data for this Ligand-Target Pair
Affinity DataKd: 2.00E+3nMAssay Description:Binding affinity to CYP2A6 (unknown origin) assessed as type 2 interaction as increase in absorbance 431 to 432 nm and decrease in 406 to 412 nmMore data for this Ligand-Target Pair
Affinity DataIC50: 2.07E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using omeprazole as substrate incubated for 5 mins followed by NADPH addition and measured after 20 m...More data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human recombinant His-tagged LSD1 (171 to 836) assessed as hydrogen peroxide formation after 5 minsMore data for this Ligand-Target Pair
Affinity DataKd: 2.30E+3nMAssay Description:Binding affinity to CYP2A13 (unknown origin) assessed as type 2 interaction as increase in absorbance 431 to 432 nm and decrease in 406 to 412 nmMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazol...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using (4S)-4,5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazol...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human recombinant MAO-B expressed in Pichia pastoris using benzylamine as substrate after 5 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of MAO-B (unknown origin) by luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human CYP2C19 by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human CYP2C19 by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.04E+3nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human recombinant CYP2C19 using CEC as substrate incubated for 50 mins by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human recombinant MAO-A expressed in Pichia pastoris using kynuramine as substrate after 5 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.64E+3nMAssay Description:Inhibition of human N-terminal GST-tagged LSD1 isoform2 (158 to end residues) expressed in Escherichia coli using methylated peptide as substrate pre...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMT: 2°CAssay Description:The interaction of SC12 with cytochrome P450 enzymes was tested using Fluorescent High Throughput P450 assays (Gentest); The IC50s of the compounds w...More data for this Ligand-Target Pair
Affinity DataKi: 5.00E+3nMAssay Description:Inhibition of human recombinant MAO-A using tyramine as substrate assessed as inhibition constant by peroxidase-coupled reaction assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.86E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes after 20 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.95E+3nMAssay Description:Inhibition of human CYP2C19 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 5.95E+3nMAssay Description:Inhibition of human recombinant CYP2C19 expressed in insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 5.95E+3nMAssay Description:Inhibition of human recombinant CYP2C19 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 5.95E+3nMAssay Description:Inhibition of human recombinant CYP2C19 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human MAOA using (4S)-4, 5-dihydro-2-(6-hydroxybenzothiazolyl)-4-thiazolecarboxylic acid substrate incubated for 60 mins by MAO-Glo ass...More data for this Ligand-Target Pair
Affinity DataKi: 6.20E+3nMAssay Description:Displacement of [3H]-di-o-tolylguanidine from Sigma 2 receptor in rat liver membrane incubated for 120 mins by solid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human CYP2B6 by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human CYP2B6 by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6.21E+3nMAssay Description:Inhibition of MAOB (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.24E+3nMAssay Description:Inhibition of human recombinant CYP2B6 expressed in insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 6.24E+3nMAssay Description:Inhibition of human CYP2B6 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 6.24E+3nMAssay Description:Inhibition of human recombinant CYP2B6 expressed in baculovirus-infected insect microsomesMore data for this Ligand-Target Pair
