BDBM439497 US10633379, Example 35::US10633379, Example 82

SMILES CCNC(=O)c1cc2c(cn(C)c(=O)c2[nH]1)-c1cc(ccc1Oc1c(C)cc(F)cc1C)C(C)(C)O

InChI Key InChIKey=OEDSFMUSNZDJFD-UHFFFAOYSA-N

Data  14 KI  12 IC50  4 Kd

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 439497   

TargetBromodomain testis-specific protein(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataKi:  1nMAssay Description:Inhibition of BRDT BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [352-457](Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataKi:  1.40nMAssay Description:Compound dilution series were prepared in DMSO via an approximately 3-fold serial dilution. Compound dilutions were added directly into white, low-vo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [352-457](Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataKi:  1.40nMAssay Description:Compound dilution series were prepared in DMSO via an approximately 3-fold serial dilution. Compound dilutions were added directly into white, low-vo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human N-terminal His6 tagged BRD4 BD2 (352 to 457) residues expressed in Escherichia coli BL21(DE3) cells after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataKi:  4.60nMAssay Description:Inhibition of N-terminal His6-tagged human BRD2 BD2 (348 to 455 residues) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataKi:  4.90nMAssay Description:Inhibition of BRD3 BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [57-168](Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataKi:  426nMAssay Description:Compound dilution series were prepared in DMSO via an approximately 3-fold serial dilution. Compound dilutions were added directly into white, low-vo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataKi:  520nMAssay Description:Inhibition of human N-terminal His6 tagged BRD4 BD1 (57 to 168) residues expressed in Escherichia coli BL21(DE3) cells after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain testis-specific protein(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataKi:  917nMAssay Description:Inhibition of BRDT BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [57-168](Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataKi:  1.03E+3nMAssay Description:Compound dilution series were prepared in DMSO via an approximately 3-fold serial dilution. Compound dilutions were added directly into white, low-vo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataKi:  1.16E+3nMAssay Description:Inhibition of N-terminal His6-tagged human BRD2 BD1 (73 to 194 residues) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataKi:  3.14E+3nMAssay Description:Inhibition of BRD3 BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataIC50:  28nMAssay Description:Inhibition of NanoLuc-tagged BRD4 BD2 (unknown origin) expressed in human HeLa cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataIC50:  2.07E+4nMAssay Description:Inhibition of NanoLuc-tagged BRD4 BD1 (unknown origin) expressed in human HeLa cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed