BDBM104692 US8569311, E-5
SMILES C[C@@H]1CC[C@@H](COc2ccc(F)cn2)CN1C(=O)c1cc(C)ccc1-c1ncccn1
InChI Key InChIKey=NPFDWHQSDBWQLH-QZTJIDSGSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 104692
Affinity DataKi: 0.200nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Antagonist activity at human OX2R by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Antagonist activity at orexin-2 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Antagonist activity at human OX2R by radioligand displacement assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Binding affinity to OX2R (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Binding affinity to orexin receptor 2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:Radioligand binding assay described in Bergman et. al. Bioorg. Med. Chem. Lett. 2008, 18, 1425-1430.More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human OX2R expressed in CHO cell membranes assessed as inhibition of orexin-A-induced intracellular calcium release after 120 ...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human OX2R by radioligand displacement assayMore data for this Ligand-Target Pair