BDBM20875 1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-3-(4-hydroxyphenyl)propan-1-one::CHEMBL241384::CHEMBL245067::JMC511145 Compound 1::O-glucoside, 1::Phlorizin

SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O

InChI Key InChIKey=IOUVKUPGCMBWBT-QNDFHXLGSA-N

Data  5 KI  36 IC50  13 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 20875   

TargetSodium/glucose cotransporter 1(Human)
Max-Planck-Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human SGLT1 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human SGLT2 expressed in COS1 cells assessed as [14C]methyl-alpha-D-glucopyranoside uptakeMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  752nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetSodium/nucleoside cotransporter 1(Human)
University of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  2.50E+5nMAssay Description:Inhibition of human CNT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/nucleoside cotransporter 2(Human)
University of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human CNT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Human)
Max-Planck-Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT1 expressed in african green monkey COS1 cells after 30 mins by liquid scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of alpha-D-[U-14C]glucopyranoside uptake at human SGLT2 expressed in african green monkey COS1 cells after 30 mins by liquid scintillation...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Human)
Max-Planck-Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  246nMAssay Description:Inhibition of human SGLT1 expressed in CHOK1 cells assessed as inhibition of glucose uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of glucose uptakeMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  36nMAssay Description:Inhibition of SGLT2More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Human)
Max-Planck-Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  330nMAssay Description:Inhibition of SGLT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 5 member 4(Human)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Human)
Max-Planck-Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Rat)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  350nMAssay Description:Inhibition of rat SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Rat)
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  96nMAssay Description:Inhibition of rat SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptakeMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptakeMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Human)
Max-Planck-Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  536nMAssay Description:Inhibition of human SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Human)
Max-Planck-Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  185nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  16.4nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Human)
Max-Planck-Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  61nMAssay Description:Inhibition of SGLT1 (unknown origin) expressed in HEK293 cells using 2-NBDG as substrate incubated for 30 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  59nMAssay Description:Inhibition of SGLT2 (unknown origin) expressed in HEK293 cells using 2-NBDG as substrate incubated for 30 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Human)
Max-Planck-Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as inhibition of [14C]alpha-methylglucopyranoside uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Human)
Max-Planck-Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  67nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose ...More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Human)
Max-Planck-Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  499nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Pig)
Daegu University

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of porcine pancreatic lipase using p-nitrophenyl butyrate as substrate pretreated for 15 mins followed by substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPancreatic triacylglycerol lipase(Pig)
Daegu University

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  6.82E+4nMAssay Description:Inhibition of recombinant human ERG expressed in HEK293 cells at -80 mV holding potential measured for 9 mins by Qpatch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human SGLT2 expressed in Xenopus oocytes assessed as reduction in [14C]AMG uptake after 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Human)
Max-Planck-Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human SGLT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human SGLT2More data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 1(Human)
Max-Planck-Institut F£R Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  210nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(White button mushroom)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of diphenolase activity of mushroom tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/nucleoside cotransporter 2(Human)
University of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human CNT2 expressed in COS7 cells assessed as reduction in sodium-dependent [14C]-inosine uptake in presence of Na+ by liquid scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Human)
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  4.17E+4nMAssay Description:Inhibition of sEH (unknown origin) assessed as substrate PHOME hydrolysis after 1 hr by fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  35nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair