BDBM50229993 2-thiourea::CHEMBL260876::Thiocarbamid::Thioharnstoff::Thiokarbamid::carbonothioic diamide::thiocarbamide::thiocarbonic acid diamide::thiourea

SMILES NC(N)=S

InChI Key InChIKey=UMGDCJDMYOKAJW-UHFFFAOYSA-N

Data  6 KI  33 IC50

PDB links: 5 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50229993   

TargetUrease(Canavalia ensiformis (Jack bean) (Horse bean))
Comsats Institute Of Information Technology

Curated by ChEMBL
LigandPNGBDBM50229993(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Affinity DataKi:  1.96E+4nMAssay Description:Inhibition of jack bean urease assessed as ammonia production after 30 mins by indophenol methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrease(Canavalia ensiformis (Jack bean) (Horse bean))
Comsats Institute Of Information Technology

Curated by ChEMBL
LigandPNGBDBM50229993(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Affinity DataKi:  2.00E+4nM IC50:  2.10E+4nMAssay Description:Reaction mixture consisting of 25 µL of Jack bean (Canavalia ensiformis) urease (1 unit/well), 55 µL of 100 mM urea dissolved in phosphate buffer (4 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrease(Canavalia ensiformis (Jack bean) (Horse bean))
Comsats Institute Of Information Technology

Curated by ChEMBL
LigandPNGBDBM50229993(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Affinity DataKi:  2.00E+4nMAssay Description:Competitive inhibition of jack bean urease using urea as substrate assessed as ammonia production after 15 mins by Lineweaver-Burk/Dixon plot analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrease(Canavalia ensiformis (Jack bean) (Horse bean))
Comsats Institute Of Information Technology

Curated by ChEMBL
LigandPNGBDBM50229993(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Affinity DataKi:  2.00E+4nM IC50:  2.10E+4nMpH: 6.8Assay Description:Reaction mixtures consisting of 25 μL (1 unit/well) of Jack bean (Canavalia ensiformis) urease, 55 μL of buffer at pH 6.8, 100 mM of urea, ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetUrease(Canavalia ensiformis (Jack bean) (Horse bean))
Comsats Institute Of Information Technology

Curated by ChEMBL
LigandPNGBDBM50229993(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Affinity DataKi:  2.30E+4nMAssay Description:Inhibition of Canavalia ensiformis (jack bean) urease assessed as release of ammonia after 30 min by indophenol methodMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAlcohol dehydrogenase E/S chain(Equus caballus)
TBA

Curated by ChEMBL
LigandPNGBDBM50229993(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)
Affinity DataKi:  4.20E+7nMAssay Description:In vitro inhibition against horse liver alcohol dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed