BDBM31892 9-cis retinoic acid::9C-RA::CHEMBL705::Panretin::alitretinoin
SMILES CC1=C(C(CCC1)(C)C)/C=C/C(=C\C=C\C(=C\C(=O)O)\C)/C
InChI Key InChIKey=SHGAZHPCJJPHSC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 150 hits for monomerid = 31892
Affinity DataKd: 0.200nMpH: 7.9 T: 2°CAssay Description:Recombinant RAR protein expressed in E. coli was used in the direct binding assay. The apparent dissociation constants (Kd) were determined by the ch...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKd: 0.300nMpH: 7.9 T: 2°CAssay Description:Recombinant RAR protein expressed in E. coli was used in the direct binding assay. The apparent dissociation constants (Kd) were determined by the ch...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Binding affinity towards cRAR-beta-2 receptor by displacing 0.82 nM 3[H]all-trans-RAMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Binding affinity towards cRAR-beta-2 receptor by displacing 0.82 nM 3[H]all-trans-RAMore data for this Ligand-Target Pair
Affinity DataKd: 0.800nMAssay Description:Dissociation constant for Retinoic acid receptor gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 0.800nMAssay Description:Agonist activity at human RAR-beta expressed in CHO-K1 cells by PathHunter assayMore data for this Ligand-Target Pair
Affinity DataKd: 0.800nMpH: 7.9 T: 2°CAssay Description:Recombinant RAR protein expressed in E. coli was used in the direct binding assay. The apparent dissociation constants (Kd) were determined by the ch...More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Agonistic activity towards retinoic acid receptor-gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at human RAR-alpha expressed in CHO-K1 cells by PathHunter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.5nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataKd: 1.5nMAssay Description:Dissociation constant for Retinoid X receptor alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 2.60nMAssay Description:Effective concentrations against Retinoic acid receptor RXR-betaMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR betaMore data for this Ligand-Target Pair
Affinity DataKd: 3nMAssay Description:Inhibition of binding to human Retinoic acid receptor RXR DEF domainMore data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Transcriptional activation for RAR beta receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Transcriptional activation of Retinoic acid receptor RAR betaMore data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Transcriptional activation of Retinoic acid receptor RAR betaMore data for this Ligand-Target Pair
Affinity DataKi: 3.80nMAssay Description:Agonistic activity towards retinoid X receptor-betaMore data for this Ligand-Target Pair
Affinity DataKd: 4nMAssay Description:Dissociation constant for binding to Retinoid X receptor gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity at human RXR-alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoic acid receptor RAR gammaMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Binding affinity against retinoic Acid X gamma receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.30nMAssay Description:Effective concentrations against Retinoic acid receptor RXR-gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 4.5nMAssay Description:Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Transcriptional activation for RAR gamma receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Transcriptional activation of Retinoic acid receptor RAR gammaMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Agonist activity at human RXR-beta expressed in U2OS cells by PathHunter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Agonist activity at human RXR-alpha expressed in U2OS cells by PathHunter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Effective concentration against Retinoic acid receptor RXR-alphaMore data for this Ligand-Target Pair
Affinity DataEC50: 6nMAssay Description:Transcriptional activation of Retinoic acid receptor RAR gammaMore data for this Ligand-Target Pair
Affinity DataKd: 7nMAssay Description:Dissociation constant for binding to Retinoic acid receptor betaMore data for this Ligand-Target Pair
Affinity DataKd: 7nMAssay Description:Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]RA as a radioligand in baculovirus expressed receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Binding affinity against retinoic Acid beta receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 7nMAssay Description:Dissociation constant for binding to Retinoic acid receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Binding affinity against retinoic Acid alpha receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 7.40nMAssay Description:Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR betaMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of [3H]targretin binding to Retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataKd: 8nMAssay Description:Transcriptional activation in CV-1 cells expressing human Retinoid X receptor RXR-alphaMore data for this Ligand-Target Pair
Affinity DataKd: 8nMAssay Description:Inhibition of [3H]-9-cis RA binding to Retinoid X receptor RXR gammaMore data for this Ligand-Target Pair
Affinity DataKi: 8.40nMAssay Description:Inhibition of [3H]9-cis-RA binding to Retinoid X receptor RXR alphaMore data for this Ligand-Target Pair
Affinity DataKd: 9nMAssay Description:Compound was tested for functional activity in CV-1 cells transfected with an expression vector for retinoid X receptor alpha using transactivation a...More data for this Ligand-Target Pair
Affinity DataKi: 9nMAssay Description:Inhibition of [3H]-Targretin binding to Retinoid X receptor RXR betaMore data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Agonist activity at human RXRalpha expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Compound was tested for binding affinity against retinoic acid receptor using 5 nM of [3H]-RA as a radioligand in baculovirus expressed receptorMore data for this Ligand-Target Pair
Affinity DataKd: 11nMAssay Description:Compound was tested for binding affinity against retinoid X receptor using 5 nM of [3H]9-cis-RA as a radioligand in baculovirus expressed receptorMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Agonistic activity towards retinoid X receptor-gammaMore data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Inhibition of [3H]ATRA binding to Retinoic acid receptor RAR betaMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Binding affinity against retinoic Acid X beta receptor using [3H]- -9-cis-Retinoic Acid in competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKd: 12nMAssay Description:Dissociation constant for binding to Retinoid X receptor betaMore data for this Ligand-Target Pair
Affinity DataEC50: 12nMAssay Description:Effective concentration against RAR-gamma receptorMore data for this Ligand-Target Pair