BDBM12370 (3-(Pyridin-3-yl)-1H-pyrazol-5-yl)methanamine::[3-(3-pyridyl)-1H-pyrazol-5-yl]methylamine;hydrochloride::[3-(pyridin-3-yl)-1H-pyrazol-5-yl]methanamine::nicotine 3-heteroaromatic analogue 32

SMILES NCc1cc(n[nH]1)-c1cccnc1

InChI Key InChIKey=OTHCSWRZZBYQIQ-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 12370   

TargetCytochrome P450 2A6(Human)
Human Biomolecular Research Institute

LigandPNGBDBM12370([3-(pyridin-3-yl)-1H-pyrazol-5-yl]methanamine | (3...)
Affinity DataKi:  300nMAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2006
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Human Biomolecular Research Institute

LigandPNGBDBM12370([3-(pyridin-3-yl)-1H-pyrazol-5-yl]methanamine | (3...)
Affinity DataIC50: 600nMpH: 7.5Assay Description:To gain insight into the selectivity of the synthetic compounds for inhibition of other CYPs, we examined the major CYPs present in human liver. Prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2015
Entry Details
US Patent

TargetCytochrome P450 2B6(Human)
TBA

US Patent
LigandPNGBDBM12370([3-(pyridin-3-yl)-1H-pyrazol-5-yl]methanamine | (3...)
Affinity DataIC50: 6.64E+4nMpH: 7.5Assay Description:To gain insight into the selectivity of the synthetic compounds for inhibition of other CYPs, we examined the major CYPs present in human liver. Prio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2015
Entry Details
US Patent

TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM12370([3-(pyridin-3-yl)-1H-pyrazol-5-yl]methanamine | (3...)
Affinity DataIC50: 1.00E+5nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/28/2011
Entry Details
PCBioAssay
TargetCytochrome P450 3A4(Human)
Human Biomolecular Research Institute

LigandPNGBDBM12370([3-(pyridin-3-yl)-1H-pyrazol-5-yl]methanamine | (3...)
Affinity DataKi: >4.00E+5nMAssay Description:To measure CYP2A6 activity, coumarin 7-hydroxylation was determined. The formation of the coumarin metabolite, 7-hydroxycoumarin, was determined fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2006
Entry Details Article
PubMed