BDBM141386 US8916600, 20::US9738632, Example 20

SMILES C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cccc(c1)C(=O)N[C@@H]1CCOC1=O)c1ccc2OCCOc2c1

InChI Key InChIKey=RBVNAVLAXTVQOZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 141386   

TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141386(US8916600, 20 | US9738632, Example 20)
Affinity DataIC50: 0.920nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141386(US8916600, 20 | US9738632, Example 20)
Affinity DataIC50: 0.930nMAssay Description:Transrepression of glucocorticoid receptor in human PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2019
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141386(US8916600, 20 | US9738632, Example 20)
Affinity DataIC50: 1.96nMAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
US Patent

TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141386(US8916600, 20 | US9738632, Example 20)
Affinity DataIC50: 1.96nMpH: 7.4 T: 2°CAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 uM. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2015
Entry Details
US Patent