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Found 4 Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM141386'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141386(US8916600, 20 | US9738632, Example 20)
Affinity DataIC50:  0.920nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141386(US8916600, 20 | US9738632, Example 20)
Affinity DataIC50:  0.930nMAssay Description:Transrepression of glucocorticoid receptor in human PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141386(US8916600, 20 | US9738632, Example 20)
Affinity DataIC50:  1.96nMpH: 7.4 T: 2°CAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 uM. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141386(US8916600, 20 | US9738632, Example 20)
Affinity DataIC50:  1.96nMAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _...More data for this Ligand-Target Pair
In DepthDetails US Patent