BDBM14489 6-{2-[4-(dimethylamino)phenyl]ethynyl}-5-phenylpyrimidin-4-amine::CHEMBL216119::alkynylpyrimidine 3

SMILES CN(C)c1ccc(cc1)C#Cc1ncnc(N)c1-c1ccccc1

InChI Key InChIKey=VXXLDNDRHRHGOU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14489   

TargetAdenosine kinase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14489(CHEMBL216119 | 6-{2-[4-(dimethylamino)phenyl]ethyn...)
Affinity DataIC50: 20nMAssay Description:Inhibition of cytosolic adenosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine kinase(Rat)
Abbott Laboratories

LigandPNGBDBM14489(CHEMBL216119 | 6-{2-[4-(dimethylamino)phenyl]ethyn...)
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:ADK activity was monitored by a radiochemical assay, which measures the conversion of radioactive Ado ([U-14C] adenosine or [2-3H] adenosine) to AMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2007
Entry Details Article
PubMed
TargetAdenosine kinase(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14489(CHEMBL216119 | 6-{2-[4-(dimethylamino)phenyl]ethyn...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of adenosine kinase in intact cells assessed as adenosine phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed