BDBM15804 Macrocyclic BACE inhibitor 6::tert-butyl N-[(2S)-1-[(2S,5S)-5-[(1S,3R)-1-hydroxy-3-methyl-3-{[(1S)-2-methyl-1-[(pyridin-4-ylmethyl)carbamoyl]propyl]carbamoyl}propyl]-2-methyl-3-oxo-1,4-diazecan-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate

SMILES CC(C)[C@H](NC(=O)[C@H](C)C[C@H](O)[C@@H]1CCCCCN([C@@H](C)C(=O)N1)C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(=O)NCc1ccncc1

InChI Key InChIKey=YXZLNUCZHUWHSH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 15804   

TargetBeta-secretase 1(Human)
Eli Lilly

LigandPNGBDBM15804(tert-butyl N-[(2S)-1-[(2S,5S)-5-[(1S,3R)-1-hydroxy...)
Affinity DataIC50: 260nMpH: 4.6 T: 2°CAssay Description:The substrate is linked to a fluorescent dye on one end and to a quenching group on its other end. The fluorescence of the substrate is significantly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2007
Entry Details Article
PubMed