BDBM18029 (6R)-6-({[1-(3-hydroxypropyl)-1,2,3,4-tetrahydroquinolin-7-yl]oxy}methyl)-1-(4-{3-[(2-methoxyphenyl)methoxy]propoxy}phenyl)piperazin-2-one::CHEMBL372416::Ketopiperazine-based inhibitor, 9

SMILES COc1ccccc1COCCCOc1ccc(cc1)N1[C@@H](COc2ccc3CCCN(CCCO)c3c2)CNCC1=O

InChI Key InChIKey=HEFYJBZEIVFECQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 18029   

TargetRenin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM18029(CHEMBL372416 | (6R)-6-({[1-(3-hydroxypropyl)-1,2,3...)
Affinity DataIC50: 37nMAssay Description:Concentration required to inhibit renin activity by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRenin(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM18029(CHEMBL372416 | (6R)-6-({[1-(3-hydroxypropyl)-1,2,3...)
Affinity DataIC50: 37nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2007
Entry Details Article
PubMed