BDBM18029 (6R)-6-({[1-(3-hydroxypropyl)-1,2,3,4-tetrahydroquinolin-7-yl]oxy}methyl)-1-(4-{3-[(2-methoxyphenyl)methoxy]propoxy}phenyl)piperazin-2-one::CHEMBL372416::Ketopiperazine-based inhibitor, 9

SMILES COc1ccccc1COCCCOc1ccc(cc1)N1[C@@H](COc2ccc3CCCN(CCCO)c3c2)CNCC1=O

InChI Key InChIKey=HEFYJBZEIVFECQ-GDLZYMKVSA-N

Data  2 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 18029   

TargetRenin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM18029((6R)-6-({[1-(3-hydroxypropyl)-1,2,3,4-tetrahydroqu...)
Affinity DataIC50:  37nMAssay Description:Concentration required to inhibit renin activity by 50%More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM18029((6R)-6-({[1-(3-hydroxypropyl)-1,2,3,4-tetrahydroqu...)
Affinity DataIC50:  37nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair