BDBM197689 US9216981, 17::US9550781, 24

SMILES Fc1ccc(NS(=O)(=O)c2ccsc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12

InChI Key InChIKey=YSBVTNXKLLPITL-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 197689   

TargetSerine/threonine-protein kinase B-raf(Human)
Medpacto

US Patent
LigandPNGBDBM197689(US9216981, 17 | US9550781, 24)
Affinity DataIC50: 7nMpH: 7.2 T: 2°CAssay Description:To check the B-Raf kinase inhibitory activity of the compounds of the present invention, the following experiments were conducted.(1) Serial Signalin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Medpacto

US Patent
LigandPNGBDBM197689(US9216981, 17 | US9550781, 24)
Affinity DataEC50:  40nMT: 2°CAssay Description:To check the B-Raf cell activity inhibitory capability of the compounds of the present invention, the following experiments were conducted in A375P c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
US Patent

TargetNuclear receptor coactivator 2 [740-753]()
Centaurus Biopharma

US Patent
LigandPNGBDBM197689(US9216981, 17 | US9550781, 24)
Affinity DataIC50: 100nMAssay Description:In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details
US Patent