BDBM25313 (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid::Alendronate::CHEMBL870::bisphosphonate, 65
SMILES NCCCC(O)(P(O)(O)=O)P(O)(O)=O
InChI Key InChIKey=OGSPWJRAVKPPFI-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 25313
Affinity DataKi: 44.2nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 minsMore data for this Ligand-Target Pair
TargetFarnesyl pyrophosphate synthase(Leishmania major)
University of British Columbia
Curated by ChEMBL
University of British Columbia
Curated by ChEMBL
Affinity DataKi: 91nMAssay Description:Inhibition of recombinant Leishmania major FPPS expressed in Escherichia coli BL21(DE3) using GPP and [14C]IPP as substrate incubated for 15 mins by ...More data for this Ligand-Target Pair
Affinity DataKi: 91nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
TargetPolyprenyl synthetase family protein(Leishmania donovani)
University of Illinois At Urbana-Champaign
Curated by ChEMBL
University of Illinois At Urbana-Champaign
Curated by ChEMBL
Affinity DataKi: 95nMAssay Description:Binding affinity towards Farnesyl diphosphate synthase from leishmania majorMore data for this Ligand-Target Pair
Affinity DataKi: 393nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21More data for this Ligand-Target Pair
TargetHypoxanthine-guanine phosphoribosyltransferase(Trypanosoma brucei brucei)
Universidad De Buenos Aires
Curated by ChEMBL
Universidad De Buenos Aires
Curated by ChEMBL
Affinity DataKi: 1.89E+5nMAssay Description:Inhibition of hypoxanthine-guanine phosphoribosyltransferase (TcHPRT)More data for this Ligand-Target Pair
Affinity DataIC50: 950nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against the human recombinant FPPSase(Farnesyl diphosphate) enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 minsMore data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign
Curated by ChEMBL
University of Illinois At Urbana-Champaign
Curated by ChEMBL
Affinity DataIC50: 4.40E+5nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
Affinity DataIC50: 2.75E+7nMpH: 7.4 T: 37°CAssay Description:The reaction was carried out at 37°C in 70 mM phosphate buffer (Na2HPO4/NaH2PO4, pH 7.4) containing the enzyme (20 μl volume, diluted 100 times ...More data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase(Human)
University of Illinois At Urbana-Champaign
Curated by ChEMBL
University of Illinois At Urbana-Champaign
Curated by ChEMBL
Affinity DataIC50: 4.37E+5nMAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
Affinity DataIC50: 955nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M)More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human FPPS expressed in Escherichia coli by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 2.25E+3nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21More data for this Ligand-Target Pair