BDBM26392 2,4-diamino-5,6-disubstituted pyrimidine, 6::6-(4-methylpiperazin-1-yl)-3,5-diazatricyclo[8.4.0.0^{2,7}]tetradeca-1(14),2,4,6,10,12-hexaen-4-amine
SMILES CN1CCN(CC1)c1nc(N)nc-2c1CCc1ccccc-21
InChI Key InChIKey=CEUMRIVIGREJGB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 26392
Affinity DataKi: 5.40nM ΔG°: -11.3kcal/molepH: 7.4 T: 25°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
Affinity DataKi: 15.5nM ΔG°: -10.6kcal/molepH: 7.4 T: 25°CAssay Description:Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...More data for this Ligand-Target Pair
Affinity DataKi: 186nMAssay Description:Displacement of [3H]histamine from human histamine 4 receptor expressed in Sf9 cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Human)
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
Curated by ChEMBL
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
Curated by ChEMBL
Affinity DataKi: 9.12E+3nMAssay Description:Displacement of [3H]mepyramine from human histamine 1 receptor expressed in Sf9 cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Human)
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
Curated by ChEMBL
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
Curated by ChEMBL
Affinity DataKi: 9.77E+3nMAssay Description:Displacement of [3H]Nalpha-methylhistamine from human histamine 3 receptor expressed in Sf9 cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
TargetHistamine H2 receptor(Human)
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
Curated by ChEMBL
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg
Curated by ChEMBL
Affinity DataKi: 3.16E+4nMAssay Description:Displacement of [3H]UR-DE257 from human histamine 2 receptor expressed in Sf9 cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataEC50: 295nMAssay Description:Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS ...More data for this Ligand-Target Pair