BDBM472784 US10829493, Example 10::US12552795, Compound 11::US20260138986, Compound 11
SMILES C[C@](N)(c1ccc(F)cc1)c1cnc(N2CCN(c3ncnn4cc(-c5cnn(C6CC(O)C6)c5)cc34)CC2)nc1
InChI Key InChIKey=HTSXPGZYHWSIKE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 472784
Affinity DataIC50: 0.300nMAssay Description:KIT D816V assay at the APPKM for ATP: In each well of a 384-well assay plate, 0.3 nM of untreated enzyme was incubated in a total of 13 μL of bu...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:All test articles were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of all test compounds was c...More data for this Ligand-Target Pair
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:All test articles were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of all test compounds was c...More data for this Ligand-Target Pair
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:All test articles were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of all test compounds was c...More data for this Ligand-Target Pair
Affinity DataKd: <0.300nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:PDGFRα (D842V):PDGFRα D842V assay at the apparent Michaelis-Menten constant(APPKM) for ATP: In each well of a 384-well assay plate, 7 nM of...More data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMAssay Description:All test articles were dissolved in 100% DMSO at a stock concentration of 10 mM. A 100×, 10-point, 4-fold serial dilution of all test compounds was c...More data for this Ligand-Target Pair
Affinity DataKd: 0.650nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Affinity DataKd: <10nMAssay Description:Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...More data for this Ligand-Target Pair
Affinity DataKd: <10nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Affinity DataKd: <10nMAssay Description:Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...More data for this Ligand-Target Pair
Affinity DataKd: <10nMAssay Description:The primary screen was performed by transient transactivation assays. These cell-based assays were carried out using Cos-7 cells transfected with a c...More data for this Ligand-Target Pair
Affinity DataKd: <10nMAssay Description:Kd Determinations. For most assays, including wt KIT kinase, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 st...More data for this Ligand-Target Pair