BDBM50027662 CHEMBL3338418

SMILES ONC(=O)c1ccc2CC[C@H](Cc2c1)Nc1nccc(n1)-c1cccnc1

InChI Key InChIKey=MWLFQRZKKHIDTM-UHFFFAOYSA-N

Data  14 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50027662   

TargetHistone deacetylase 6(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50: 48nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50: 50nMAssay Description:Inhibition of HDAC6 (unknown origin) using fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50: 80nMAssay Description:Inhibition of HDAC8 (unknown origin) using fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50: 80nMAssay Description:Inhibition of HDAC8 (unknown origin) using RHK(Ac)K(Ac)AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataEC50:  1.60E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataEC50:  1.64E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as tubulin acetylation after 17 to 18 hrs by cytoblot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50: 3.08E+4nMAssay Description:Inhibition of HDAC7 (unknown origin) using fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of HDAC9 (unknown origin) using fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC3 (unknown origin) using fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC2 (unknown origin) using fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC11 (unknown origin) using fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC5 (unknown origin) using fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC10 (unknown origin) using fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Roche Pharmaceutical Research and Early Development

Curated by ChEMBL
LigandPNGBDBM50027662(CHEMBL3338418)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC4 (unknown origin) using fluorogenic peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed