BDBM50038623 2-(2-Benzyl-3-mercapto-5-methyl-hexanoylamino)-propionic acid::CHEMBL55286

SMILES CC(C)CC(S)C(Cc1ccccc1)C(=O)NC(C)C(O)=O

InChI Key InChIKey=YBIZKEFULFLDEE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50038623   

TargetNeprilysin(Rabbit)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50038623(2-(2-Benzyl-3-mercapto-5-methyl-hexanoylamino)-pro...)
Affinity DataIC50: 3.60nMAssay Description:Tested for inhibitory potency against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetNeprilysin(Rabbit)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50038623(2-(2-Benzyl-3-mercapto-5-methyl-hexanoylamino)-pro...)
Affinity DataIC50: 14nMAssay Description:Inhibitory concentration was evaluated by Inhibiting 50% of Neutral endopeptidase enzyme (NEP) activity using 20 nM [3H]D-Ala2-Leu-enkephalin as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50038623(2-(2-Benzyl-3-mercapto-5-methyl-hexanoylamino)-pro...)
Affinity DataIC50: 4.00E+3nMAssay Description:Tested for binding affinity against ThermolysinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
University of Paris

Curated by ChEMBL
LigandPNGBDBM50038623(2-(2-Benzyl-3-mercapto-5-methyl-hexanoylamino)-pro...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibitory concentration was evaluated by inhibiting 50% of Angiotensin I Converting Enzyme activity using 50 uM N-Cbz-Phe-His-Leu as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed