BDBM50038623 2-(2-Benzyl-3-mercapto-5-methyl-hexanoylamino)-propionic acid::CHEMBL55286

SMILES CC(C)CC(S)C(Cc1ccccc1)C(=O)NC(C)C(O)=O

InChI Key InChIKey=YBIZKEFULFLDEE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50038623   

TargetNeprilysin(Oryctolagus cuniculus (rabbit))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50038623(2-(2-Benzyl-3-mercapto-5-methyl-hexanoylamino)-pro...)
Affinity DataIC50:  3.60nMAssay Description:Tested for inhibitory potency against neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50038623(2-(2-Benzyl-3-mercapto-5-methyl-hexanoylamino)-pro...)
Affinity DataIC50:  4.00E+3nMAssay Description:Tested for binding affinity against ThermolysinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50038623(2-(2-Benzyl-3-mercapto-5-methyl-hexanoylamino)-pro...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibitory concentration was evaluated by inhibiting 50% of Angiotensin I Converting Enzyme activity using 50 microM N-Cbz-Phe-His-Leu as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50038623(2-(2-Benzyl-3-mercapto-5-methyl-hexanoylamino)-pro...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration was evaluated by Inhibiting 50% of Neutral endopeptidase enzyme (NEP) activity using 20 nM [3H]-D-Ala2-Leu-enkephalin as sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed