BDBM50074897 2-[4-(7-Ethoxy-2,3-bis-hydroxymethyl-6-methoxy-naphthalen-1-yl)-pyridin-2-yl]-4-pyridin-3-yl-2H-phthalazin-1-one; hydrochloride::CHEMBL552877

SMILES CCOc1cc2c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c(CO)c(CO)cc2cc1OC

InChI Key InChIKey=MZWIXTAQIAHGBV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50074897   

LigandPNGBDBM50074897(2-[4-(7-Ethoxy-2,3-bis-hydroxymethyl-6-methoxy-nap...)
Affinity DataIC50: 0.160nMAssay Description:In vitro inhibition of Phosphodiesterase 4 from guinea pig lungMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50074897(2-[4-(7-Ethoxy-2,3-bis-hydroxymethyl-6-methoxy-nap...)
Affinity DataIC50: 490nMAssay Description:In vitro inhibition of Phosphodiesterase 3 activity from guinea pig cardiac ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50074897(2-[4-(7-Ethoxy-2,3-bis-hydroxymethyl-6-methoxy-nap...)
Affinity DataIC50: 800nMAssay Description:Inhibition of Phosphodiesterase 5 of guinea pig lungMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50074897(2-[4-(7-Ethoxy-2,3-bis-hydroxymethyl-6-methoxy-nap...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Phosphodiesterase 1 of guinea pig cardiac ventricleMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed