BDBM50171264 CHEMBL197646::US11427604, Compound (I-43)::US11597738, Example 1::[2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine

SMILES CN(C)CCc1c[nH]c2cccc(F)c12

InChI Key InChIKey=ISJZKVWGUWBUFG-UHFFFAOYSA-N

Data  6 KI  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50171264   

Target5-hydroxytryptamine receptor 2B(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50171264([2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine ...)
Affinity DataKi:  8.39nMAssay Description:Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50171264([2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine ...)
Affinity DataKi:  82nMAssay Description:Inhibition constant against human 5-hydroxytryptamine 2C receptor [INI isoforms] using [3H]mesulergine as radioligand with the compound (10 uM) disso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50171264([2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine ...)
Affinity DataKi:  84nMAssay Description:Inhibition constant against human 5-hydroxytryptamine 2C receptor [VGI isoforms] using [3H]mesulergine as radioligand with the compound (10 uM) disso...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50171264([2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine ...)
Affinity DataEC50:  99nMAssay Description:Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50171264([2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine ...)
Affinity DataKi:  335nMAssay Description:Inhibition constant against human 5-hydroxytryptamine 2A receptor using [3H]ketanserin as radioligand with the compound (10 uM) dissolved in DMSOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Organix

Curated by ChEMBL
LigandPNGBDBM50171264([2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine ...)
Affinity DataKi:  359nMAssay Description:Inhibition constant against rat 5-hydroxytryptamine 2C receptor using [3H]mesulergine as radioligand with the compound (10 uM) dissolved in DMSOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50171264([2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine ...)
Affinity DataIC50: 500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2023
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50171264([2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine ...)
Affinity DataIC50: 500nMAssay Description:Table 2: i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2  4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50171264([2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine ...)
Affinity DataEC50:  949nMAssay Description:Effective concentration required for accumulation of [3H]inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Organix

Curated by ChEMBL
LigandPNGBDBM50171264([2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine ...)
Affinity DataKi:  1.01E+3nMAssay Description:Inhibition constant against rat 5-hydroxytryptamine 2A receptor using [3H]ketanserin as radioligand with the compound (10 uM) dissolved in DMSOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Organix

Curated by ChEMBL
LigandPNGBDBM50171264([2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine ...)
Affinity DataEC50:  1.18E+3nMAssay Description:Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor det...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed