BDBM50171264 CHEMBL197646::US11427604, Compound (I-43)::US11597738, Example 1::[2-(4-Fluoro-1H-indol-3-yl)-ethyl]-dimethyl-amine

SMILES CN(C)CCc1c[nH]c2cccc(F)c12

InChI Key InChIKey=ISJZKVWGUWBUFG-UHFFFAOYSA-N

Data  6 KI  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50171264   

Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171264(CHEMBL197646 | US11427604, Compound (I-43) | US115...)
Affinity DataKi:  8.39nMAssay Description:Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]-LSD as radioligand with the compound (10 uM) dissolved in DMSOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171264(CHEMBL197646 | US11427604, Compound (I-43) | US115...)
Affinity DataKi:  82nMAssay Description:Inhibition constant against human 5-hydroxytryptamine 2C receptor [INI isoforms] using [3H]-mesulergine as radioligand with the compound (10 uM) diss...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171264(CHEMBL197646 | US11427604, Compound (I-43) | US115...)
Affinity DataKi:  84nMAssay Description:Inhibition constant against human 5-hydroxytryptamine 2C receptor [VGI isoforms] using [3H]-mesulergine as radioligand with the compound (10 uM) diss...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171264(CHEMBL197646 | US11427604, Compound (I-43) | US115...)
Affinity DataKi:  335nMAssay Description:Inhibition constant against human 5-hydroxytryptamine 2A receptor using [3H]-ketanserin as radioligand with the compound (10 uM) dissolved in DMSOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Organix

Curated by ChEMBL
LigandPNGBDBM50171264(CHEMBL197646 | US11427604, Compound (I-43) | US115...)
Affinity DataKi:  359nMAssay Description:Inhibition constant against rat 5-hydroxytryptamine 2C receptor using [3H]-mesulergine as radioligand with the compound (10 uM) dissolved in DMSOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Organix

Curated by ChEMBL
LigandPNGBDBM50171264(CHEMBL197646 | US11427604, Compound (I-43) | US115...)
Affinity DataKi:  1.01E+3nMAssay Description:Inhibition constant against rat 5-hydroxytryptamine 2A receptor using [3H]-ketanserin as radioligand with the compound (10 uM) dissolved in DMSOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171264(CHEMBL197646 | US11427604, Compound (I-43) | US115...)
Affinity DataIC50: <500nMAssay Description:Table 2: i. Prepare the assay buffer following the table below;Reagent ConcentrationTris 50 mMCaCl2  4 mMBSA 0.1% (w/v)Adjust pH to 7.4 followe...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171264(CHEMBL197646 | US11427604, Compound (I-43) | US115...)
Affinity DataEC50:  1.18E+3nMAssay Description:Effective concentration required for accumulation of [3H]-inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor de...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171264(CHEMBL197646 | US11427604, Compound (I-43) | US115...)
Affinity DataEC50:  949nMAssay Description:Effective concentration required for accumulation of [3H]-inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2A receptor determi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171264(CHEMBL197646 | US11427604, Compound (I-43) | US115...)
Affinity DataEC50:  99nMAssay Description:Effective concentration required for accumulation of [3H]-inositol phosphate in cells stably expressing human 5-hydroxytryptamine 2C receptor determi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50171264(CHEMBL197646 | US11427604, Compound (I-43) | US115...)
Affinity DataIC50: <500nMMore data for this Ligand-Target Pair
In DepthDetails US Patent