BDBM50202092 CHEMBL386029::N-[(E)-5-fluoro-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide

SMILES FC(F)(F)c1ccc(nc1)N1CCN(CC(=O)N[C@H]2C3CC4CC2C[C@](F)(C4)C3)CC1

InChI Key

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50202092   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202092(N-[(E)-5-fluoro-2-adamantyl]-2-{4-[5-(trifluoromet...)
Affinity DataKi:  32nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coli by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202092(N-[(E)-5-fluoro-2-adamantyl]-2-{4-[5-(trifluoromet...)
Affinity DataKi:  120nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coli by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202092(N-[(E)-5-fluoro-2-adamantyl]-2-{4-[5-(trifluoromet...)
Affinity DataIC50: 550nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells by FPIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202092(N-[(E)-5-fluoro-2-adamantyl]-2-{4-[5-(trifluoromet...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against human 11beta-HSD2 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mouse)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202092(N-[(E)-5-fluoro-2-adamantyl]-2-{4-[5-(trifluoromet...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against mouse 11beta-HSD2 by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed