BDBM50212293 (1S,9R,10R)-5-amino-20-(cyclopropylmethyl)-6-thia-4,20-diazapentacyclo[8.7.3.0^{1,9}.0^{3,7}.0^{12,17}]icosa-3(7),4,12(17),13,15-pentaen-15-ol::CHEMBL226217

SMILES Nc1nc2C[C@]34CCN(CC5CC5)[C@H](Cc5ccc(O)cc35)[C@@H]4Cc2s1

InChI Key

Data  3 KI  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50212293   

TargetKappa-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212293((1S,9R,10R)-5-amino-20-(cyclopropylmethyl)-6-thia-...)
Affinity DataKi:  0.0700nMAssay Description:Displacement of [3H]U-69593 from human kappa opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212293((1S,9R,10R)-5-amino-20-(cyclopropylmethyl)-6-thia-...)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212293((1S,9R,10R)-5-amino-20-(cyclopropylmethyl)-6-thia-...)
Affinity DataEC50:  0.170nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO membrane assessed as stimulation of [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212293((1S,9R,10R)-5-amino-20-(cyclopropylmethyl)-6-thia-...)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]naltrindole from human delta opioid receptor expressed in CHO membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212293((1S,9R,10R)-5-amino-20-(cyclopropylmethyl)-6-thia-...)
Affinity DataEC50:  0.340nMAssay Description:Antagonist activity at human kappa opioid receptor expressed in CHO membrane assessed as inhibition of U50488-induced [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212293((1S,9R,10R)-5-amino-20-(cyclopropylmethyl)-6-thia-...)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO membrane assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212293((1S,9R,10R)-5-amino-20-(cyclopropylmethyl)-6-thia-...)
Affinity DataEC50:  0.610nMAssay Description:Agonist activity at human kappa opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by scintilla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212293((1S,9R,10R)-5-amino-20-(cyclopropylmethyl)-6-thia-...)
Affinity DataIC50: 1.80nMAssay Description:Antagonist activity at human mu opioid receptor transfected in CHO cells assessed as inhibition of U50488-induced [35S]GTPgammaS binding after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50212293((1S,9R,10R)-5-amino-20-(cyclopropylmethyl)-6-thia-...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human mu opioid receptor expressed in CHO membrane assessed as inhibition of DAMGO-induced [35S]GTP-gamma-S bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed