BDBM50216175 CHEMBL425828::N-[(1S,2R)-2-amino-1-benzyl-3-methoxypropyl]-2-(methyl{[(1S,2S)-2-methylcyclopropyl]methyl}amino)-6-[methyl(methylsulfonyl)amino]isonicotinamide

SMILES COC[C@H](N)[C@H](Cc1cc(F)cc(F)c1)NC(=O)c1cc(nc(c1)N(C)S(C)(=O)=O)N(C)C[C@H]1C[C@@H]1C

InChI Key InChIKey=ZNARZYKTJODECI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50216175   

TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216175(N-[(1S,2R)-2-amino-1-benzyl-3-methoxypropyl]-2-(me...)
Affinity DataIC50: 12nMAssay Description:Inhibition of BACE1 by ECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216175(N-[(1S,2R)-2-amino-1-benzyl-3-methoxypropyl]-2-(me...)
Affinity DataIC50: 173nMAssay Description:Inhibition of BACE1 assessed as effect on soluble APPbeta N-terminal fragment secretion in HEK293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed