BDBM50216178 CHEMBL394850::N-[(1S)-1-benzyl-2-hydroxyethyl]-2-[(cyclopropylmethyl)(propyl)amino]-6-[(isopropylsulfonyl)(methyl)amino]isonicotinamide

SMILES CCCN(CC1CC1)c1cc(cc(n1)N(C)S(=O)(=O)C(C)C)C(=O)N[C@H](CO)Cc1cc(F)cc(F)c1

InChI Key InChIKey=IKGRUPPYIQOVJN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50216178   

TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216178(N-[(1S)-1-benzyl-2-hydroxyethyl]-2-[(cyclopropylme...)
Affinity DataIC50: 350nMAssay Description:Inhibition of BACE1 by ECL assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50216178(N-[(1S)-1-benzyl-2-hydroxyethyl]-2-[(cyclopropylme...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of BACE1 assessed as effect on soluble APPbeta N-terminal fragment secretion in HEK293T cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed