BDBM50272187 CHEMBL4128554

SMILES NC(=N)c1ccc(NC(=O)[C@H](NS(=O)(=O)c2ccc(F)cc2)C2CCCCC2)cc1

InChI Key InChIKey=YNTJJZQMTAZQND-LJQANCHMSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50272187   

TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50272187(CHEMBL4128554)
Affinity DataIC50: >1.40E+4nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human uPA (M1 to L431 residues) expressed in mouse NS0 cells using Z-GGR-AMC as substrate after 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50272187(CHEMBL4128554)
Affinity DataIC50:  90nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50272187(CHEMBL4128554)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of doxycycline induced Hepsin in human MCF10A cells using Boc-QRR-AMC as substrate preincubated for 24 hrs followed by doxycycline inducti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50272187(CHEMBL4128554)
Affinity DataIC50:  2.80E+5nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human uPA (M1 to L431 residues) expressed in mouse NS0 cells using Z-GGR-AMC as substrate after 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
University of Helsinki

Curated by ChEMBL
LigandPNGBDBM50272187(CHEMBL4128554)
Affinity DataIC50:  190nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed