BDBM50274355 CHEMBL484358::N-[N'-(4-Ethynylcyclohex-3-en-1-yl)-N'-propyl-4-aminobutyl]-4-biphenylcarboxamide

SMILES CCCN(CCCCNC(=O)c1ccc(cc1)-c1ccccc1)C1CCC(=CC1)C#C

InChI Key InChIKey=PWZPBZQTTHOCIS-UHFFFAOYSA-N

Data  6 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50274355   

TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50274355(N-[N'-(4-Ethynylcyclohex-3-en-1-yl)-N'-propyl-4-am...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]spiperone from human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50274355(N-[N'-(4-Ethynylcyclohex-3-en-1-yl)-N'-propyl-4-am...)
Affinity DataKi:  0.780nMAssay Description:Displacement of [3H]spiperone from human wild type D3 receptor expressed in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50274355(N-[N'-(4-Ethynylcyclohex-3-en-1-yl)-N'-propyl-4-am...)
Affinity DataEC50:  1.60nMAssay Description:Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells by [3H]thymidine incorporation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50274355(N-[N'-(4-Ethynylcyclohex-3-en-1-yl)-N'-propyl-4-am...)
Affinity DataEC50:  2.10nMAssay Description:Intrinsic activity at human D3 receptor expressed in CHO dhfr- cells assessed as inhibition of forskolin-induced cAMP releaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50274355(N-[N'-(4-Ethynylcyclohex-3-en-1-yl)-N'-propyl-4-am...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]spiperone from human D4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50274355(N-[N'-(4-Ethynylcyclohex-3-en-1-yl)-N'-propyl-4-am...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]spiperone from human D2long receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50274355(N-[N'-(4-Ethynylcyclohex-3-en-1-yl)-N'-propyl-4-am...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]spiperone from human D2short receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Pig)
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50274355(N-[N'-(4-Ethynylcyclohex-3-en-1-yl)-N'-propyl-4-am...)
Affinity DataKi:  2.90E+3nMAssay Description:Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed