BDBM50276140 CHEMBL4129995
SMILES CCCCCCCCCCCCCC(=S)NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)Nc1ccccc1
InChI Key InChIKey=CJQGLLUJIVNREL-HKBQPEDESA-N
Data 18 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 18 hits for monomerid = 50276140
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of human SIRT1 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-6(Homo sapiens (Human))
Cornell University
Curated by ChEMBL
Cornell University
Curated by ChEMBL
Affinity DataIC50: >8.30E+4nMAssay Description:Inhibition of human SIRT6 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ followed by substrate additio...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human SIRT3 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human SIRT5 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-6(Homo sapiens (Human))
Cornell University
Curated by ChEMBL
Cornell University
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human SIRT6 (1 to 294 residues) expressed in Escherichia coli Rosetta (DE3) using H3K9AcWW as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant human SIRT2 deacylation activity using Fluor de Lys Sirt2 as substrate measured at 5 mins interval for 30 mins in presence ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of recombinant human SIRT2 defatty-acylase activity using SFP3 as substrate measured at 5 mins interval for 60 mins in presence of NAD+ by...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged/SUMO-fused SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 assessed as reduction...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human SIRT1 deacetylase activity using acetylated H3K9 as substrate preincubated for 15 mins followed by substrate addition and measure...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human SIRT3 assessed as reduction in deacetylase activity using acetylated H3K9 as substrate preincubated for 15 mins followed by subst...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: >8.30E+4nMAssay Description:Inhibition of human SIRT1 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ followed by substrate additio...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 93nMAssay Description:Inhibition of human SIRT2 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ by HPLC analysisMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of human SIRT2 deacetylation activity using H3K9Ac as substrate in presence of NAD+ by HPLC analysisMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of human SIRT2 defatty-acylation activity using peptide substrate preincubated in presence of NAD+ followed by substrate addition by HPLC ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: >8.30E+4nMAssay Description:Inhibition of human SIRT2 defatty-acylation activity using peptide substrate in presence of NAD+ by HPLC analysisMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: >8.30E+4nMAssay Description:Inhibition of human SIRT3 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ followed by substrate additio...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: >8.30E+4nMAssay Description:Inhibition of human SIRT5 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ followed by substrate additio...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nagoya City University
Curated by ChEMBL
Nagoya City University
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubate...More data for this Ligand-Target Pair