BDBM50282851 (S)-2-[(S)-2-((S)-2-Mercaptomethyl-3-phenyl-propionylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid::CHEMBL49920

SMILES C[C@H](NC(=O)[C@@H](CS)Cc1ccccc1)C(=O)N1Cc2ccccc2C[C@H]1C(O)=O

InChI Key InChIKey=UACOVYDVQRXMCG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50282851   

TargetNeprilysin(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50282851((S)-2-[(S)-2-((S)-2-Mercaptomethyl-3-phenyl-propio...)
Affinity DataIC50: 3.90nMAssay Description:In vitro inhibition of rat kidney neutral endopeptidase (NEP) by fluorometric assay using Dansyl-Gly-Phe-Arg as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetNeprilysin(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50282851((S)-2-[(S)-2-((S)-2-Mercaptomethyl-3-phenyl-propio...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of neutral endopeptidase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme(Rabbit)
TBA

Curated by ChEMBL
LigandPNGBDBM50282851((S)-2-[(S)-2-((S)-2-Mercaptomethyl-3-phenyl-propio...)
Affinity DataIC50: 14nMAssay Description:In vitro inhibition of rabbit lung Angiotensin I converting enzyme (ACE) using Hippuryl-His-Leu as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50282851((S)-2-[(S)-2-((S)-2-Mercaptomethyl-3-phenyl-propio...)
Affinity DataIC50: 14nMAssay Description:Inhibition of angiotensin-converting enzyme (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed