BDBM50306424 2-{1'-[(adamantan-2-yl)carbamoyl]-6-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL597676

SMILES Cc1ccc2C(CC(O)=O)CC3(CCN(CC3)C(=O)NC3C4CC5CC(C4)CC3C5)c2c1

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50306424   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306424(2-{1'-[(adamantan-2-yl)carbamoyl]-6-methyl-2,3-dih...)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306424(2-{1'-[(adamantan-2-yl)carbamoyl]-6-methyl-2,3-dih...)
Affinity DataIC50: 22.5nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytes assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306424(2-{1'-[(adamantan-2-yl)carbamoyl]-6-methyl-2,3-dih...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed