BDBM50306430 2-[(3S)-1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl]acetic acid::CHEMBL602249

SMILES OC(=O)C[C@@H]1CC2(CCN(CC2)C(=O)NC2C3CC4CC(C3)CC2C4)c2c1cccc2Br

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50306430   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306430(2-[(3S)-1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306430(2-[(3S)-1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytes assessed as conversion of [3H]cortisone to [3H]cortisol after 2 hrs by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50306430(2-[(3S)-1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed