BDBM50307083 4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate::CHEMBL606201::US11753371, Compound JZL-195::US20240308985, Comparator TableD2.1

SMILES [O-][N+](=O)c1ccc(OC(=O)N2CCN(Cc3cccc(Oc4ccccc4)c3)CC2)cc1

InChI Key InChIKey=QNYRAEKLMNDRFY-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50307083   

TargetFatty-acid amide hydrolase 1(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human FAAH incubated for 5 mins followed by substrate addition by cayman fluorescence based multimode microplate reader ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant FAAH (unknown origin) expressed in COS7 cells assessed as blockade of substrate hydrolysis using 2-AG as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant MAGL incubated for 5 mins followed by substrate addition by cayman fluorescence based multimode microplate reader ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant MAGL (unknown origin) expressed in COS7 cells assessed as blockade of substrate hydrolysis using AEA as substrate preincuba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetFatty-acid amide hydrolase 1(Mouse)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 13nMAssay Description:Inhibition of FAAH in mouse brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human FAAH using AMC-AA as substrate preincubated for 10 mins followed by substrate addition measured after 2 hrs by fluoro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human MAGL preincubated for 10 mins followed by substrate addition and measured every 10 sec for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant FAAH using AMC-AA as substrate preincubated with enzyme for 10 mins followed by substrate addition for 2 hrs by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant FAAH assessed as substrate hydrolysis using 7-amino-4-methyl2H-1-benzopyran-2-one-5Z,8Z,11Z,14Z-eicosatetraenamide as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetMonoglyceride lipase(Mouse)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 19nMAssay Description:Inhibition of MAGL in mouse brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 40nMAssay Description:FAAH inhibition assay was performed using Fatty Acid Amide Hydrolase Inhibitor Screening Assay Kit (Item #10005196), Cayman (1180 E Ellsworth Rd Ann ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
US Patent

TargetFatty-acid amide hydrolase 1(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 40nMAssay Description:FAAH inhibition assay was performed using Fatty Acid Amide Hydrolase Inhibitor Screening Assay Kit (Item #10005196), Cayman (1180 E Ellsworth Rd Ann ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetMonoacylglycerol lipase ABHD6(Mouse)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 50nMAssay Description:Inhibition of ABHD6 in mouse brain membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 205nMAssay Description:Inhibition of human recombinant MAGL pre-incubated for 5 mins before MAGL substrate addition and further incubated for 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 459nMAssay Description:MAGL inhibitor compounds were also counter-screened for FAAH inhibition potency using the following assay. Assessment of FAAH inhibition was performe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent

TargetFatty-acid amide hydrolase 1(Human)
Indian Institute of Technology (Banaras Hindu University)

Curated by ChEMBL
LigandPNGBDBM50307083(4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carb...)
Affinity DataIC50: 459nMAssay Description:MAGL inhibitor compounds were also counter-screened for FAAH inhibition potency using the following assay. Assessment of FAAH inhibition was performe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent