BDBM50327827 1-(4-Nitrophenyl)-3-(1-propionylpiperidin-4-yl)urea::CHEMBL1258106::US10322118, Urea-Based Scaffold Entry 10::US9296693, 20

SMILES CCC(=O)N1CCC(CC1)NC(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI Key InChIKey=UMXCVEHDFUBEMH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50327827   

TargetBifunctional epoxide hydrolase 2(Human)
Department of Entomology and University of California Davis Cancer Center

Curated by ChEMBL
LigandPNGBDBM50327827(1-(4-Nitrophenyl)-3-(1-propionylpiperidin-4-yl)ure...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant soluble epoxide hydrolase by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Department of Entomology and University of California Davis Cancer Center

Curated by ChEMBL
LigandPNGBDBM50327827(1-(4-Nitrophenyl)-3-(1-propionylpiperidin-4-yl)ure...)
Affinity DataIC50: 38nMpH: 7.0Assay Description:IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2017
Entry Details
US Patent

TargetBifunctional epoxide hydrolase 2(Human)
Department of Entomology and University of California Davis Cancer Center

Curated by ChEMBL
LigandPNGBDBM50327827(1-(4-Nitrophenyl)-3-(1-propionylpiperidin-4-yl)ure...)
Affinity DataIC50: 38nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent

TargetBifunctional epoxide hydrolase 2(Mouse)
University of California

US Patent
LigandPNGBDBM50327827(1-(4-Nitrophenyl)-3-(1-propionylpiperidin-4-yl)ure...)
Affinity DataIC50: 97nMpH: 7.0Assay Description:IC50 values were determined using a sensitive fluorescent based assay (Anal. Biochem. 2005, 343, 66-75). Cyano(2-methoxynaphthalen-6-yl)methyl trans-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2017
Entry Details
US Patent

TargetBifunctional epoxide hydrolase 2(Mouse)
University of California

US Patent
LigandPNGBDBM50327827(1-(4-Nitrophenyl)-3-(1-propionylpiperidin-4-yl)ure...)
Affinity DataIC50: 97nMAssay Description:Inhibition of mouse recombinant soluble epoxide hydrolase by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2011
Entry Details Article
PubMed
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
Dartmouth College

US Patent
LigandPNGBDBM50327827(1-(4-Nitrophenyl)-3-(1-propionylpiperidin-4-yl)ure...)
Affinity DataIC50: 4.00E+4nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
US Patent